A father's fight, a son's future: The power of plasma

Plasma donations help kids like Oliver, celebrity chef Nate Appleman’s son, live healthy lives.

Diagnostics Testing|Nov. 18, 2025

Plasma — the yellowish liquid that makes up about 55% of our blood1 — is a major component in creating lifesaving therapies for burn injury survivors, people who are immune-compromised, people with rare conditions, like hemophilia, and certain cancer patients.2 In fact, more than 125,000 Americans rely on therapies made from plasma every day,3 and to add perspective, a whopping 130 plasma donations are needed to treat one person with primary immunodeficiency for one year.4 To meet this growing need, a consistent supply from donors is crucial.

Take Oliver. When he was just 2 years old and the family had recently moved to New York, he developed a high fever, a swollen tongue, and a rash over his entire body. A visit to the emergency room resulted in a diagnosis of scarlet fever, but as Nate and Oliver were left waiting to be discharged, a serendipitous encounter with an infectious disease specialist changed everything. This doctor suggested the possibility of Kawasaki disease, a rare condition that primarily affects children under the age of five and is the leading cause of acquired heart disease in children.5

Following the doctor's advice, Nate took Oliver for further tests. The subsequent ultrasound revealed a devastating diagnosis: four giant aneurysms on Oliver's coronary arteries, a severe complication that raises the risk of blood clots and can lead to a heart attack or cause bleeding inside the body.5 Nate vividly recalls the “hardest walk of my life” as he carried his son to the hospital, grappling with the terrifying reality of Oliver's critical state.

Oliver spent more than a month in the hospital receiving intravenous immunoglobulin (aka IVIG), a therapy derived from plasma. He eventually returned home, beginning a lifelong regimen of medication to manage his heart health, a lasting complication.

“On one hand, I was sad that my son was suffering, but on the other hand, I realized I could do something about it,” his father, celebrity chef Nate Appleman said. “I could use my skills as a chef. I could get my chef buddies together. I could do fundraisers. And I could take that money and put it towards research on immune deficiencies."

Reflecting on the past 16 years since Oliver’s initial diagnosis, Nate speaks of profound lessons learned: the critical importance of donating plasma, the need for continued research, the collective effort to help others, and how this experience transformed him into a more aware and compassionate individual. Oliver, now 18 and looking forward to graduation, is a testament to the power and the incredible gift of plasma. In fact, Oliver was recently able to donate for the first time himself, and in doing so paying forward the life-saving gift he received.

Donating plasma is a safe and easy process. While donation rules may vary by country, in general, you can donate plasma as often as twice a week.6 With a donation that typically takes between 1-3 hours, you can make a lasting impact on patients who rely on plasma for treatment.7 Within 24 hours, the plasma volume you donated is replenished in your body.7

While Oliver works on keeping his heart healthy, Nate continues to feed others with his culinary skills, and with the knowledge he’s gained through Oliver’s resilience.

In the spirit of Nate and Oliver’s health journey, and giving back, here’s a recipe to remember:

Ingredients

  • A pinch of willingness to donate
  • A dash of generosity
  • 1-3 hours of your time

Mix ingredients together — and potentially save somebody’s life.

Learn more about plasma donation and how to become a donor by visiting BeThe1Donor.com.

References

1 American Red Cross. What is plasma in blood? RedCrossBlood.org. https://www.redcrossblood.org/donate-blood/dlp/plasma-information.html. Accessed November 3, 2025.

2 United States Department of Health and Human Services. Why Giving Plasma is So Critical. Hhs.gov. https://www.hhs.gov/givingequalsliving/giveplasma/why-give. Accessed November 3, 2025.

3 APLUS. Statement on the State of Plasma. DonatingPlasma.org. https://www.donatingplasma.org/images/COVID/APLUS_Statement_on_the_State_of_Plasma_Aug2020.pdf. Published August 2020. Accessed November 3, 2025.

4 Department of Health and Human Services. Why Giving Plasma is So Critical. hhs.gov. https://www.hhs.gov/givingequalsliving/giveplasma/why-give. Accessed November 3, 2025.

5 Mayo Clinic. Kawasaki Disease. MayoClinic.org. https://www.mayoclinic.org/diseases-conditions/kawasaki-disease/symptoms-causes/syc-20354598. Accessed November 3, 2025.

6 United States Department of Health and Human Services. Giving Blood and Plasma. Hhs.gov. https://www.hhs.gov/oidp/topics/blood-tissue-safety/giving-blood-plasma/index.html. Accessed November 3, 2025.

7 American Red Cross. Frequently Asked Questions. RedCrossBlood.org. https://www.redcrossblood.org/faq.html. Accessed September 29, 2025.

This story was originally published in January of 2022.